Therefore, their use in mostly local infection in the eyes, ears, skin. In 1939 G Domagk (Germany) won the Nobel Prize for his discovery of anti-bacterial effect of prontosil and slough . Roksitromitsin and clarithromycin appointed interior, 2 times a day, azithromycin - 1 time per day. With the chemotherapeutic effect of antibiotics may be related: 1) the reaction is acute, 2) dysbiosis (superinfection). Aminoglycosides act on the slough ribosomal subunit. Aminoglycosides are used mainly for severe infections caused by susceptible micro-organisms to slough (Sepsis, peritonitis, urinary tract infections, pneumonia, wound and burn infection). Chance of pseudomembranous colitis associated with suppression of normal intestinal microflora Niemi (strong abdominal cramping, diarrhea, bloody stools). Neomycin Gastric Ulcer more toxic, is used only locally. To macrolides are also midekamitsin (macroporous silicon) dzhosamitsin spiro-ching (rovamitsin). By means of violating the exchange of folic acid include: a) sulfanilamids, b) derivatives of diamin slough combination of drugs sulfonamides and trimethoprim. Effective in relative shenii Mycobacterium tuberculosis. Distinguish 3 generations of aminoglycosides: I generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III slough amikacin, netilmicin. Practically not absorbed in the gastrointestinal tract, so they are administered parenterally. Streptomycin - a broad spectrum antibiotic. To aminoglycosides slough generation is also tobramycin, similar in properties and applications with gentamicin. The drug is not absorbed slough the gastrointestinal tract, it can appoint inside with enteritis, as well as to suppress here microbial slough of intestinal ne-ed surgery. Erythromycin is used in pharyngitis, diphtheria, pneumonia, prostatitis, caused by chlamydia, ureaplasma, and syphilis, if benzylpenicillin not apply, for the prevention of pertussis. Externally as an ointment Gentamicin is used in pyoderma, infected wounds, eye (in the form here eye drops ointment) - with blepharitis, conjunctivitis, keratitis. Streptomycin is effective against cocci, Hib, klebsi-ell, agents of tularemia, slough brucellosis, Shigella, Salmonella. The drug is also used in brucellosis (with doxycycline), plague, and tularemia. Organotropic side effects of antibiotics varied. Violate the initial stages of protein synthesis on the ribosomes of bacteria: education policy and the correct reading of the mRNA. Bactericidal action of aminoglycosides. With the destruction of the mass of microbial cells Hyperthermia occurs, which indicates a high efficiency are chosen antibiotic slough passes quickly when continuation of chemotherapy. Aminoglycosides - broad-spectrum antibiotics. Used topically for treatment of infected cuts, scrapes, and burns. Dysbacteriosis develops in antibiotic suppression of the normal slough of the body. Well pro-arise in the bone tissue. Side effects of rifampicin: flu-like syndrome, disorders of the function slough liver and kidney, slough blurred vision, disturbances menstrual cycle, skin reactions, red-brown staining of the lacrimal fluid, sweat, urine. Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). Intramuscularly or intravenously drip. In contrast to the drugs I generation gentamicin acts on Pseudomonas aeruginosa. Chloramphenicol inhibits hepatic microsomal enzymes and, therefore, may exacerbate the effects of drugs, which are inactivated by these enzymes. Chloramphenicol was appointed interior, and in severe cases, intravenously. Side effects of macrolides: nausea, reversible hearing loss, violation of liver function, allergic reaction. For slough tetracyclines, suppressing the normal gut can cause intestinal candidiasis. Therefore, tetracyclines are usually appointed interior with drug effective against the fungi Candida slough nistati-nom).
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